.Writers as well as AffiliationsDana-Farber Cancer Cells Institute, Brigham and also Womenu00e2 $ s Healthcare facility and Harvard Medical College, Boston Ma, MA, USAToni K. Choueiriu00c2 & u00c2 William G. Kaelin JrHoward Hughes Medical Institute, Chevy Chase, MD, USAWilliam G. Kaelin JrCorresponding authorsCorrespondence to.Toni K. Choueiri or William G. Kaelin Jr.